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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9c59e2206a658063316c5bd9b21b86b91119ef20d5fb1cd380b8d039479bab10' 
  AND token = 'IhgKCt4B6ImTjZVdTMcrEtMB+/SIG8S1Rgxh6MOuDMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}