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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d46bd5a3686ed0330e6b43925895373f1373a4a3a0b32cab4c25cfbd069388' 
  AND token = 'uyd5mNCj+4zky2x1yGSxoetJC/+EPX3H3QmnsVqH1+E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}