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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f21c8ff73e6245556d9e02b1a88aeb23d9ebd2f05c019e32b55ac289e7e8ea78' 
  AND token = 'SH64IrbHOsvqqOaleyKUWNhqeEprK1Uu+8DZRSz80+g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}