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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1561da43cd3e9839458d687ab7cc4cb91568586d192ba9ed1b36cd406da7f701' 
  AND token = 'UyRYxZQHy2LL4vPlrg6ka6UCcJ9icQOgw1lhxTt1bfo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}