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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f7b810031932af217ae023b47c5cf05e8e4c8d16fc34109104090314724ec5' 
  AND token = 'W16f6QZ8ZNXkzmr+JKmODA8X7axKnN1tKdXcisRpIrk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}