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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d45859b7ac73b0fca779f213a3e7c5e4a76f236baad6d0452d88bc19e0061ca' 
  AND token = 'MrcXFanfaddrBrBdEOR5ZttpFxCOVmIVxPGxZUFnIug=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}