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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d69cffe2a7a642b540f5e954d1c7c3095ca4ea37620fb2df69e7f1c644f2deb' 
  AND token = 'zNRC6NRM8DpZEQTcbfBm42Yya6i250kC+93SRWLUINw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}