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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c65d5328696f2d6d00de8170985f268d369c05b1d06688568c78046959dd7d8f' 
  AND token = 'V0WML9X0ZU+azp6SR3NMhyXYO1LhxC19Irm/vDTZiWI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}