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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e3fbff005d9a904e835e9620d8aa1c8139784c9e0eaccd0e2023676fb9e4361' 
  AND token = 'Sb6ym9KYE0uYWBwOmDe27VGSTclx+HC0WL8hgus1IBA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}