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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '257d6393199a11697b403b74619a20173b96f0a0f21df94ba90dbfecb8ec1bbb' 
  AND token = 'LOWMwsDWCcqxGixz5e9vLKLcKGlrGRDExAY22Q1huTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}