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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ab21afd87d180827d63dae9dd1501e53ec74e3137ac88e02570e9e5cbccb0fa1' 
  AND token = '+SfCxq46wC10MyUiivEC78h7yx+qP8LlO/q+vaPBy7Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}