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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '463514c6a95f6e0943622e94e3a5a0c514a8f649166cdd4ddfe3ffedacf25754' 
  AND token = 'DOhEsNSZAkYYXrbwNkHJbg0wSpFU4GMV/7vQ/8DW4mM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}