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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dfd6e32972bc57535c6439778d4461c22aca3c6ac5e49343f107e920fda419ef' 
  AND token = 'pLIOEC69UaNTINCVrgpuEIGYN9VuvEvjvB016AgJwbI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}