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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65e4ccc2726321d6e1979ca5aa537b75a7c4f04f53f933e853862622bbc14532' 
  AND token = 'JCVndyTWG3mGLedujrMdyORGEl9h36+UMc8rLzvUT2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}