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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3fe6ad4d3c0b963e132310e2475f2498d009f6777e2696f9446225a714c2aa59' 
  AND token = 'OKMesPCE6M/K8c1HCv+CRxsmY5Cd81KjtsWmmoTv6EU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}