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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c5473dd82a22266ae2b3db524e2e24d0e957e7e64057d9e885f605715b2f49' 
  AND token = 'yX1Uon399Er1MSGeZ/YUpZFuxxVZYIVzpKwy5/jeMyA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}