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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8e254af484176b31f12ae54e41b87e35b17e28b722dbfec919c89ed0820df29' 
  AND token = 'inG1DuuKXEPb9RTAF4//VT3+imvMO8fPwE9FGU2w1Rw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}