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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dfffd28301ad614678b93e7cf1383c4576e19d0ba5869bf78a624d43c6eb57e0' 
  AND token = '1mTosMBS++bD4Ny+YHs6Tv042n1i4IJDWa4m2O6ZDjg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}