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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c898bf5eb57472aa75b2481798921679d29a6b39c5e06a5c7c021e758d6d065' 
  AND token = 'OzUSUplQMLFd2r+ESAYtPkcjdciVKI1ZOc9OOJ1JP6Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}