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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78126cb3f779eaa4b9f6e12e26fecba2f24f28c075150398b53f3a3eca01811c' 
  AND token = '2ZPDJhQhcLmXJuNQaMaKMUtUwIDXpnt3A5Gd2s+aJt8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}