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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd7533f9f51e77b754f97d46828138f7eaed21aa0bf08b4e9254662c5231c51c' 
  AND token = 'S5UFbIyHP24hNetO6jgfaSF0o5CMQL3EEqLQkhRmqrc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}