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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd22c8374cc81913b552395f4eebe615f3ff1a8c64956054b12391a0c1599cd4a' 
  AND token = 'YqX/+9lK7zsBaCCE7OyAW+8sf2LBeQsbzjlyN1+9Qlg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}