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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7f40a7568ad1c3e8409a7e6d28a54f1e89c39a995d0a68b79deb8e4e79b48356' 
  AND token = 'OoAx8YDiXyGm1NUjnaVWktNc8s40dW+qrMpko7eeUWw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}