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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '894d2fff2d37a7a16cd195e9dda2afdb69076f06db07e1d9b061f163060eeb9f' 
  AND token = 'Jq5pj/PCSDYGNC+HQYYwd06fzBxhxExbfMQVIsDLJOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}