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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2421c2491ade51e9b52baef0be53fe4f1f397456577076296d5657c318f229b9' 
  AND token = 'SRBm0kixxN+1bRt1yAHo8ZZ3DLVS4LFvTsuwxALkRWw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}