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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9c5f3d52f42033c46c8ca2a33d4d4e6185f06562222a4a5f1c454f0df8017146' 
  AND token = 'iZrWf0N9uUGcApcVqnabGmSsz7E0ZYTGYJ5JWXltpHE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}