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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c8e181ac9bcf4d1c871248118a31fa9e32133f607b0e181fae1fae952c06ec1' 
  AND token = 'On9icUSzPhigfiT64yHFgfzQq/35xJXyT5SkSx9qOxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}