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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273b4f970f6db2581a7b2a1529fd8a873bbd752a1fe8d880c7d2b812f873c495' 
  AND token = 'EIvv7wRJr4Y4ExeAGVVSFy3nZnFJ7bH56C3Jfx88dOI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}