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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c353246c9d79b1f3f3b669ed2d06fc2228ee6e836d435fd4e0fa0983469865a' 
  AND token = 'iCVR0MAL+MTbt0QxFdVvmWfXZHlAbl5FYqJ0u4DQkFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}