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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53004e80186a51d05a4f34bdb768dd0b103867441b3c73b138d576c6c2c5ed6e' 
  AND token = 'Kxcqj6EU+uzhB+Dd3hfZHWVXmMQ1pHF8QoaFrM0ZF2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}