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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6364c3508d0f4ae688a4bdd227fedce78509607de20a180a6318a2dde98a471' 
  AND token = '8Xeqbit7BEEFbCxW9VEweb25HxLiYwxz7FhJR2aYWLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}