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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643af601e020aaa1c3ab6b0ab5976101670afab7de8dcc8b45924c172064a185' 
  AND token = '3q1VegufzkAuphUoqlqZA6zli+xfH0u+6HpsOQOYoTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}