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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421de37a811e70e33ec7b1714962a76125c37786079130e55405e488fba25ccd' 
  AND token = '0Gn2tkXTWMo4xD7W054kj15/qkhEJTyIGulIEo/yKwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}