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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4bcf45628d034338e55f5de3b10d8075c73d3a42e8e186804be3ab0fd4b3d064' 
  AND token = 'NO1YVVRQ/lfXRbPp3RyTl34W55l4arob7EvAc/5w7UA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}