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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e27f64b523ec970c5cc0b8d1731c7d73a1167f4c3f6f023815446d60fdeceb71' 
  AND token = 'XbYnuIA6UK1LsLQav3cnalNlQoqQQ01dDAxxM8UQj98=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}