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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a06d68780ab9ef62caa293c65cf180ce66f5e9d5519f671bbe0628ad7ea59f9f' 
  AND token = 'ucNpAWngd96ouP0qzfC8vMmO7+vLwRvVQ25UJ5WTcqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}