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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '412c9f34f6d14dd7132543cf1f1a779028db72543cb090c63b026c8193f3a61f' 
  AND token = 'o/vjlwCymy6+EDz22unaPMHNFLCptOeAJcsXMAc6ibs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}