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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e05705349d20f2b36a4aaa1daed013d48273ac5e50113fecf54e314f4edd590' 
  AND token = '2lQDASQMXKUwzG8QnZzbjakH/locttzPO443QUV6eNM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}