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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25a74bcc38c59a04422d7db2fa0f70b7ba2ec98948868416812d9d39dd8cf1c7' 
  AND token = 'srtQEd12IAR7FuC3ZLa5h2fbS3iRPbtTvQ29TCsTqu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}