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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '89fcbb606c2d5858d65506afa4c14c0486d3d158b5e7ee7db05ce65fbd8cf159' 
  AND token = '45SIYR1HUsp3ZN6VB3C+sFNvwR1+vp+4PuMYWs0+pAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}