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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f5723a8d0496c1366106149a6a4c693fa163222ccfa60a63c48851bce8b72ea' 
  AND token = 'uMzA7+U6fTPHmtO+VtXMFPDmn/3Fqc/dI7mbHkjHkl4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}