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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5691adf9c0a0bc18f929f95dbc0450ccd42b5bbba5813e4ef05e799a690b4268' 
  AND token = 'I6pQUm8bAAOetp1Dbdtp6V9KUbD68P0Wj6d8w/xOE5A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}