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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e6b6a516dac964c991acbf73787f0287edc50707a4a03883bfac727929e0e9d' 
  AND token = 'B8uTH5BE15u3X0/uAh1z/P4NnzMkcr24Yo5Ky6ZNuNw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}