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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af6c6f8eb9a5309e6f3ff339a3730b7fdce7b37e3dd3b1d94107a724c2184536' 
  AND token = 'FlRA1983TYHNiLPe/jm3IHkNfCDLWReK0KU1db0X+8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}