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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce2280e3dd48102c1766a697423769698b8c9758e5f0229af4f13ff1e4400363' 
  AND token = 'UDIZbqmcRGJH+oYA2y7s0i6g6FiDGfPFQ5q39IfYDc8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}