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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46bbd6f3d9016bfd8a106d51f84c3e8e9356ef7b06a3c600c6227b146a320458' 
  AND token = 'GgPMtyYwdkocPu2jtyXDEx/6n4XW102ZhYks+PpDY+U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}