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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '644d8d3bbf10ebb2602fda98ab069127ca508bc81fd150d68ca0d79609465255' 
  AND token = 'EHVEX262eftWCZmdaFAj/NYPQdhREYvZaNWuRNMdCt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}