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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a12ce5d9057441d5489361a33ba622c86e485d68ec25cc1399dd6a2459cecf5' 
  AND token = 'EHTwmRml8XZrY1EK0ZP0FrkqNDFw1olpezdu5BBqKqc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}