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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52b251d71486c5988020ee39fa6f08d5e5a496fd0dcd68a004a92a0e6e5ce781' 
  AND token = '/MAl8kWdG7456ELhhWndlWplKGXvN4tktBbOem8jV7U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}