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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b69ad60cde8eadd754540caa6dba03f53b3b533b511f8221cb72e8188e8e59c' 
  AND token = 'SPZiF48Wwgwuh0NplrVDg1EGf+0pQmL7O6j4Bk7C4no=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}